Antony Starr’s Homelander seeks God mode in the final season.

The Boys season 5 trailer reveals full Supernatural reunion as Jensen Ackles chokes out Misha Collins

Antony Starr's Homelander seeks God mode in the final season.

By Nick Romano

Nick Romano is a senior editor at ** with 15 years of journalism experience covering entertainment. His work previously appeared in *Vanity Fair*, Vulture, IGN, and more.

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March 5, 2026 12:01 p.m. ET

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Misha Collins and Jensen Ackles on 'The Boys' season 5. Credit:

- *Supernatural* stars Jensen Ackles, Jared Padalecki, and Misha Collins reunite in *The Boys* season 5 trailer.

- The final season preview shows Antony Starr's Homelander seeking immortality and Karl Urban's Butcher rampaging to stop him.

- It's the final countdown as we barrel towards the series finale, dropping May 20 after a season premiere on April 28.

The *Supernatural* men are officially back together on *The Boys*.

The trailer for the fifth and final season of Amazon's R-rated superhero satire reveals a first look at the onscreen reunion of Jensen Ackles, Jared Padalecki, and Misha Collins — casting which was announced back in February 2025.

The footage shows Homelander (Antony Starr), who's hellbent on reaching immortal god status, waking up his father, Soldier Boy (Ackles), from cryogenic stasis. "Did you f--- me?" Soldier Boy wants to know upon waking up in his underwear and a "Sorry, Snowflake" Homelander top.

Soldier Boy's team-up with his son for total domination will lead to an encounter with two characters played by Padalecki and Collins. Details on those roles are still elusive, but the *Supernatural* gents, who portrayed Sam Winchester and Castiel, are seen now in gaudy button-downs within a massive mansion.

Jared Padalecki arrives in 'The Boys' season 5 first-look trailer

'Vought Rising,' 'Gen V' crossover potential teased by Eric Kripke (exclusive)

*The Boys* season 5 trailer provides us a first look at Collins' character getting choked out by Soldier Boy. It's a reunion that's been years in the making. Eric Kripke, *The Boys* showrunner who created *Supernatural*, has been working to get his boys back together, but schedules proved to be an issue.

Multiple other alumni from the long-running series have already made the jump to *The Boys*, including Jeffrey Dean Morgan.

The final season, which takes place after the events of *Gen V* season 2, will realize the final battle for the soul of America. With Homelander exacting an iron, dictatorial will across the country, Hughie (Jack Quaid), Mother’s Milk (Laz Alonso), and Frenchie (Tomer Capone) are imprisoned in a "Freedom Camp." Meanwhile, Annie (Erin Moriarty) attempts to mount a resistance against the supes, and Kimiko (Karen Fukuhara) — who's now talking! — is nowhere to be found.

Jared Padalecki, Misha Collins, and Jensen Ackles. Kevin Mazur/Getty Images

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During this low point for our heroes, Butcher (Karl Urban) reappears with his sights set on acquiring a virus that will wipe all supes off the map.

The first two episodes will premiere on Amazon's Prime Video streaming platform on April 8, following by a weekly release. The series finale is set for May 20.

Watch the trailer above.**

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Source: “EW Superhero”